program
Day 3 │Thursday 2 February |
|
KEYNOTE LECTURE |
|
Chair: Michael Potente |
|
8.30 – 9.10 |
The Dos and Don’ts of Shaping a Blood Vessel Network Holger Gerhardt │ Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany |
9.10 – 9.15 |
Patient story |
SESSION ARTERIO-VENOUS MALFORMATIONS & RAS-MAPK SIGNALING |
|
Chairs: Roberto Latini and Marle Kraft |
|
9.15 – 9.45 |
Cell-cell communication during arteriovenous specification Ralf Adams │ Max Planck Institute for Molecular Biomedicine, Münster, Germany |
9.45 – 10.00 |
Novel insights on the mechanisms of formation and resolution of arteriovenous malformations Claudio Franco │ University of Lisbon, Portugal |
10.00– 10.30 |
Decoding the molecular mechanisms of mutant KRAS-driven brain arteriovenous malformations Jason Fish │ University of Toronto, Canada |
10.30 – 10.50 |
Coffee break |
10.50 – 11.05 |
Functional Testing of Novel Mosaic RIT1 Mutations Identified in Patients with Arteriovenous Malformations Paves the Way for Targeted Therapy Friedrich Kapp │ Division of Pediatric Hematology and Oncology, Medical Center – University of Freiburg, Germany |
11.05 – 11.35 |
Mechanisms Underlying the Progression and Regression of Arteriovenous Malformation Rong Wang │ University of California San Francisco, USA |
11.35 – 11.50 |
Single-cell dissection of human brain arteriovenous malformations Ethan Winkler │ University of California San Francisco, USA |
11.50 – 12.10 |
Theranostic management of AVMs Laurence Boon │ Centre for Vascular Malformations, Cliniques universitaires Saint-Luc, Brussels, Belgium
|
POSTER TEASERS |
|
Chairs: Roberto Latini and Marle Kraft |
|
12.10 – 12.15 |
Endoglin cell-autonomously restricts venous endothelial cell size to prevent arteriovenous malformations in zebrafish Zeenat Diwan │University of Pennsylvania, USA |
12.15 – 12.20 |
ALK1 is critical for maintenance of pulmonary and liver endothelium integrity Nicolas Ricard │ Grenoble Alpes University, INSERM UMR1292, France |
12.20 – 12.25 |
Dysfunctional BMP-9/ALK-1 contributes to angiogenic vessel remodeling in pulmonary hypertension Nihel Berrebeh │ Université Paris-Saclay, France |
12.25 – 13.05 |
Lunch |
POSTER SESSION |
|
13.05 – 14.25 |
Poster session 2 (odd numbers + teasers of Thursday) |
14.25 – 14.30 |
Patient story |
KEYNOTE LECTURE |
|
Chair: Lars Jakobsson |
|
14.30 – 15.10 |
Lymphatic vessel type-specific functions of BMP signaling An Zwijsen │ KU Leuven, Belgium |
SESSION HEREDITARY HAEMORRHAGIC TELANGIECTASIA (HHT) / BMP |
|
Chairs: Mat François and Murat Alpaslan |
|
15.10 – 15.30 |
Links between BMP9 & BMP10 and hereditary haemorrhagic telangiectasia (HHT) Sabine Bailly │ VA Cure – Grenoble Alpes University, INSERM UMR1292, CEA, France |
15.30 – 15.45 |
Heterozygous ALK1-mutated endothelial cells display normal transcriptomic responses to BMP9 and BMP10 supporting the need of second hit for driving HHT pathogenesis Tala Al Tabosh │ VA Cure – Grenoble Alpes University, INSERM UMR1292, CEA, France |
15.45 – 16.00 |
Klf4 is a key determinant factor for AVM pathogenesis in HHT-JP mouse model Roxana Ola │ Medical Faculty Mannheim, Heidelberg University, Germany |
16.00 – 16.15 |
Induced-cell cycle arrest prevents arterio-venous malformations in Hereditary Hemorrhagic Telangiectasia Gael Genet │ University of Virginia, Charlottesville, USA |
16.15 – 16.35 |
Coffee break |
16.35 – 16.55 |
Regulation of vessel size – knowledge from the malforming vasculature in HHT1 Lars Jakobsson │ VA Cure – Karolinska Institutet, Stockholm, Sweden |
16.55 – 17.10 |
Deciphering early phosphoproteome changes in response to BMP9 and BMP10 in endothelial cells Mohammad Al Tarrass │ Grenoble Alpes University, INSERM UMR1292, CEA, France |
17.10 – 17.40 |
Clinical trials in HHT Sophie Dupuis-Girod │ HHT Reference center, Hospices Civils de Lyon, INSERM U1292, France |
CAREER OPTIONS SESSION |
|
Chair: Joseph Lim |
|
17.40 – 18.30 |
Career options for scientists outside academia. Panel members: Iiro EEROLA │ Policy Officer, European Commission, DG Research & Innovation, Brussels, Belgium Jamila LOUAHED │ VP Head of Vaccines Global Research and Development, Belgium R&D center, GSK Vaccines Bethan Phillips │Publisher Vascular Biology, Bioscientifica |
Congress dinner at Hotel Le Plaza |
|
Day 3 │Thursday 2 February |
|
KEYNOTE LECTURE |
|
Chair: Michael Potente |
|
8.30 – 9.10 |
The Dos and Don’ts of Shaping a Blood Vessel Network Holger Gerhardt │ Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany |
9.10 – 9.15 |
Patient story |
SESSION ARTERIO-VENOUS MALFORMATIONS & RAS-MAPK SIGNALING |
|
Chairs: Roberto Latini and Marle Kraft |
|
9.15 – 9.45 |
Cell-cell communication during arteriovenous specification Ralf Adams │ Max Planck Institute for Molecular Biomedicine, Münster, Germany |
9.45 – 10.00 |
Novel insights on the mechanisms of formation and resolution of arteriovenous malformations Claudio Franco │ University of Lisbon, Portugal |
10.00– 10.30 |
Decoding the molecular mechanisms of mutant KRAS-driven brain arteriovenous malformations Jason Fish │ University of Toronto, Canada |
10.30 – 10.50 |
Coffee break |
10.50 – 11.05 |
Functional Testing of Novel Mosaic RIT1 Mutations Identified in Patients with Arteriovenous Malformations Paves the Way for Targeted Therapy Friedrich Kapp │ Division of Pediatric Hematology and Oncology, Medical Center – University of Freiburg, Germany |
11.05 – 11.35 |
Mechanisms Underlying the Progression and Regression of Arteriovenous Malformation Rong Wang │ University of California San Francisco, USA |
11.35 – 11.50 |
Single-cell dissection of human brain arteriovenous malformations Ethan Winkler │ University of California San Francisco, USA |
11.50 – 12.10 |
Theranostic management of AVMs Laurence Boon │ Centre for Vascular Malformations, Cliniques universitaires Saint-Luc, Brussels, Belgium
|
POSTER TEASERS |
|
Chairs: Roberto Latini and Marle Kraft |
|
12.10 – 12.15 |
Endoglin cell-autonomously restricts venous endothelial cell size to prevent arteriovenous malformations in zebrafish Zeenat Diwan │University of Pennsylvania, USA |
12.15 – 12.20 |
ALK1 is critical for maintenance of pulmonary and liver endothelium integrity Nicolas Ricard │ Grenoble Alpes University, INSERM UMR1292, France |
12.20 – 12.25 |
Dysfunctional BMP-9/ALK-1 contributes to angiogenic vessel remodeling in pulmonary hypertension Nihel Berrebeh │ Université Paris-Saclay, France |
12.25 – 13.05 |
Lunch |
POSTER SESSION |
|
13.05 – 14.25 |
Poster session 2 (odd numbers + teasers of Thursday) |
14.25 – 14.30 |
Patient story |
KEYNOTE LECTURE |
|
Chair: Lars Jakobsson |
|
14.30 – 15.10 |
Lymphatic vessel type-specific functions of BMP signaling An Zwijsen │ KU Leuven, Belgium |
SESSION HEREDITARY HAEMORRHAGIC TELANGIECTASIA (HHT) / BMP |
|
Chairs: Mat François and Murat Alpaslan |
|
15.10 – 15.30 |
Links between BMP9 & BMP10 and hereditary haemorrhagic telangiectasia (HHT) Sabine Bailly │ VA Cure – Grenoble Alpes University, INSERM UMR1292, CEA, France |
15.30 – 15.45 |
Heterozygous ALK1-mutated endothelial cells display normal transcriptomic responses to BMP9 and BMP10 supporting the need of second hit for driving HHT pathogenesis Tala Al Tabosh │ VA Cure – Grenoble Alpes University, INSERM UMR1292, CEA, France |
15.45 – 16.00 |
Klf4 is a key determinant factor for AVM pathogenesis in HHT-JP mouse model Roxana Ola │ Medical Faculty Mannheim, Heidelberg University, Germany |
16.00 – 16.15 |
Induced-cell cycle arrest prevents arterio-venous malformations in Hereditary Hemorrhagic Telangiectasia Gael Genet │ University of Virginia, Charlottesville, USA |
16.15 – 16.35 |
Coffee break |
16.35 – 16.55 |
Regulation of vessel size – knowledge from the malforming vasculature in HHT1 Lars Jakobsson │ VA Cure – Karolinska Institutet, Stockholm, Sweden |
16.55 – 17.10 |
Deciphering early phosphoproteome changes in response to BMP9 and BMP10 in endothelial cells Mohammad Al Tarrass │ Grenoble Alpes University, INSERM UMR1292, CEA, France |
17.10 – 17.40 |
Clinical trials in HHT Sophie Dupuis-Girod │ HHT Reference center, Hospices Civils de Lyon, INSERM U1292, France |
CAREER OPTIONS SESSION |
|
Chair: Joseph Lim |
|
17.40 – 18.30 |
Career options for scientists outside academia. Panel members: Iiro EEROLA │ Policy Officer, European Commission, DG Research & Innovation, Brussels, Belgium Jamila LOUAHED │ VP Head of Vaccines Global Research and Development, Belgium R&D center, GSK Vaccines Bethan Phillips │Publisher Vascular Biology, Bioscientifica |
Congress dinner at Hotel Le Plaza |
|