{"id":973,"date":"2022-07-09T14:19:34","date_gmt":"2022-07-09T14:19:34","guid":{"rendered":"https:\/\/vacure-conference.net\/?page_id=973"},"modified":"2023-01-16T17:09:45","modified_gmt":"2023-01-16T17:09:45","slug":"keynote-speakers","status":"publish","type":"page","link":"https:\/\/vacure-conference.net\/index.php\/keynote-speakers\/","title":{"rendered":"Keynote speakers"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"973\" class=\"elementor elementor-973\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a82b4d3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a82b4d3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2fe0549\" data-id=\"2fe0549\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2a78134 elementor-widget elementor-widget-heading\" data-id=\"2a78134\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Keynote speakers<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f1d9aee elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f1d9aee\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#2c2c2c;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-divider 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data-id=\"d84d66a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"399\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/10\/Anne-Eichmann.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/10\/Anne-Eichmann.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/10\/Anne-Eichmann-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/10\/Anne-Eichmann-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8622717 elementor-widget elementor-widget-text-editor\" data-id=\"8622717\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.6.5 - 27-04-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h3>Anne Eichmann<\/h3><div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ad1297 elementor-widget elementor-widget-text-editor\" data-id=\"5ad1297\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Ensign Professor of Medicine (Internal Medicine-Cardiology) <\/p><p>Yale University, New Haven, USA<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-9f1a489\" data-id=\"9f1a489\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-97a426c elementor-widget elementor-widget-text-editor\" data-id=\"97a426c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Dr. Eichmann obtained her M.Sc. at the Weizmann Institute in Rehovot, Israel, and a Ph.D. in molecular and cell biology from the Universit\u00e9 Paris XIII. She came to Yale School of Medicine in 2010, where she now is Ensign Professor of Medicine and Professor of Cellular And Molecular Physiology.<\/p><p>Research in her group concerns the vascular system, its development and contribution to human pathologies. The long-term goal is to understand the cellular and molecular mechanisms controlling vascular patterning. They aim to identify key molecular events underlying angiogenesis, lymphangiogenesis and arteriogenesis and to establish the principles governing development of the vertebrate vascular system. Their studies on arteriovenous malformations that occur in hereditary hemorrhagic telangiectasia (HHT) have lead to the identification of aberrant molecular signaling pathways that may represent novel therapeutic targets to reduce epistaxis in HHT patients. The group\u2019s work on tip cells and VEGF signaling has profoundly affected scientific thinking about vascular patterning.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-320097b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"320097b\" data-element_type=\"section\" id=\"bio-Vanhaesebroeck\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-922b312\" data-id=\"922b312\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3b42a4f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b42a4f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0b37134\" data-id=\"0b37134\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4ddb0c0 elementor-widget elementor-widget-image\" data-id=\"4ddb0c0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Prof-Bart-Vanhaesebroeck-rond.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Prof-Bart-Vanhaesebroeck-rond.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Prof-Bart-Vanhaesebroeck-rond-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Prof-Bart-Vanhaesebroeck-rond-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e2c89f elementor-widget elementor-widget-text-editor\" data-id=\"1e2c89f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Bart Vanhaesebroeck<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cbda509 elementor-widget elementor-widget-text-editor\" data-id=\"cbda509\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Professor of Cell Signalling <\/p><p>UCL Cancer Institute, London, UK<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-99b9192\" data-id=\"99b9192\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f624b0 elementor-widget elementor-widget-text-editor\" data-id=\"8f624b0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Following a PhD in the Laboratory of Molecular Biology at Ghent University (Belgium), Bart Vanhaesebroeck performed postdoctoral studies in London at the Ludwig Institute for Cancer Research. Here, he was involved in gene cloning and biochemical characterisation of PI 3-kinase (PI3K) isoforms, leading to the discovery of the PI3K gene family. In his independent laboratory, his team developed the first so-called \u2018kinase-dead\u2019 mice, and generated the largest series of PI3K mouse models world-wide. These models allowed them and their collaborators to uncover the organimal roles of multiple PI3K family members, their potential as drug targets and to faithfully predict PI3K inhibitor activity in vivo.<\/p><p>A highlight of their work was the discovery of the leukocyte-enriched PI3Kdelta isoform. His team took PI3Kdelta from gene cloning and preclinical modelling to the commercial generation of PI3Kdelta-inhibitors and the development of clinical strategies to inhibit this PI3K. These studies underpinned the approval of PI3Kdelta inhibitors for leukaemia and their emerging use in solid tumour immunotherapy. His current research focuses on understanding PI3K biology in health and disease, and the development of novel ways to modulate PI3K signalling, with potential applications in oncology, cell protection and tissue regeneration, as well as cancer prevention.<\/p><p>Bart Vanhaesebroeck is an elected member of EMBO and of the UK Academy of Medical Sciences.<\/p><div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0ef5c5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0ef5c5b\" data-element_type=\"section\" id=\"bio-Tournier-Lasserve\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-db1c572\" data-id=\"db1c572\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-05c006e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"05c006e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-9184e37\" data-id=\"9184e37\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f9cc2a6 elementor-widget elementor-widget-image\" data-id=\"f9cc2a6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"399\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/09\/Tournier-Lasserve2.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/09\/Tournier-Lasserve2.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/09\/Tournier-Lasserve2-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/09\/Tournier-Lasserve2-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a9c4a7d elementor-widget elementor-widget-text-editor\" data-id=\"a9c4a7d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Elisabeth Tournier-Lasserve<\/h3><div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9e4678 elementor-widget elementor-widget-text-editor\" data-id=\"e9e4678\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Professor of Medical Genetics<\/p><p>Paris Cit\u00e9 University, France<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-2a05131\" data-id=\"2a05131\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-029988f elementor-widget elementor-widget-text-editor\" data-id=\"029988f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Dr. Elisabeth Tournier-Lasserve obtained her MD from the University of Paris in 1984. After her residency, she worked as a \u201cchef de clinique\u201d in neurology at Piti\u00e9-Salp\u00eatri\u00e8re hospital for 2 years and then moved for 3 years to the National Institute of Health in Bethesda in the Molecular Biology research lab head by Pr RA Lazzarini. She is currently Professor of Medical Genetics at Paris Cit\u00e9 University, Director of the National Reference French Genetics Diagnostic lab for Neurovascular Disorders in Saint Louis hospital in Paris, and Director of the GeneMedStroke research team at INSERM U1141, focusing on Genetics and pathophysiological mechanisms of Neuro-Vascular disorders.<\/p><p>Her main resarch interest in the past 25 years was focused on hereditary neurovascular disorders. She\u00a0 characterized the clinical features of several hereditary neurovascular disorders, revealed their molecular mechanisms and developed diagnostic tools for these conditions to improve clinical care and genetic counseling for patients and families.<\/p><div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dce1b37 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dce1b37\" data-element_type=\"section\" id=\"bio-Gerhardt\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-933c7a3\" data-id=\"933c7a3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b39fa4a elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b39fa4a\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d81d6c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d81d6c4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-660eb11\" data-id=\"660eb11\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7cb8a6c elementor-widget elementor-widget-image\" data-id=\"7cb8a6c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Holger-Gerhardt-rond-1.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Holger-Gerhardt-rond-1.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Holger-Gerhardt-rond-1-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Holger-Gerhardt-rond-1-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-811464c elementor-widget elementor-widget-text-editor\" data-id=\"811464c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Holger Gerhardt<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a084643 elementor-widget elementor-widget-text-editor\" data-id=\"a084643\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Professor in Experimental Cardiovascular Research at the Charit\u00e9 and BIH and Head of the Integrative Vascular Biology Laboratory at the MDC in Berlin, Germany<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-7b2f96f\" data-id=\"7b2f96f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b94c9cf elementor-widget elementor-widget-text-editor\" data-id=\"b94c9cf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Holger Gerhardt obtained his PhD with Hartwig Wolburg at the University of T\u00fcbingen. Following a post-doc with Christer Betsholtz at the University of G\u00f6teborg, he set up his own group at the Cancer Research UK London Research Institute, and later a joint-venture with the VIB, Leuven. He is currently the Speaker of the German Cardiovascular Research Center (DZHK) at the Partnersite Berlin, and of the Berlin Center for Translational Vascular Biomedicine, as well as the MDC Topic Integrative Biomedicine. <\/p><p>His research is focussed on the fundamental principles and molecular mechanisms regulating the formation and adaptation of vascular networks in development and disease. Recent achievements include the discovery of the mechanism of vascular lumen formation by inverse membrane blebbing under blood pressure, the identification of a phase transition in Notch signaling dynamics that switch blood vessel formation from branching to expansion, a role for YAP\/TAZ signaling in controlling junctional dynamics and plasticity to enable endothelial cell rearrangements whilst keeping vessels tight, and a role of primary cilia in endothelial cells sensitizing nascent vessels to the stabilizing activity of BMP under blood flow. Studies in zebrafish highlight how the balance of arteries and veins is achieved and how microtubule modifications can control fate determination in lymphovenous specification. These examples signify the ongoing efforts in unravelling how endothelial cells collectively integrate mechanical and chemical stimuli to achieve functional vascular patterning and pave the way towards translational research into maladaptive behavior in disease.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c4d0319 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c4d0319\" data-element_type=\"section\" id=\"bio-Zwijsen\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c192f0b\" data-id=\"c192f0b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8e74aee elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8e74aee\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-acedd5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"acedd5b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4d1d894\" data-id=\"4d1d894\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-696d9de elementor-widget elementor-widget-image\" data-id=\"696d9de\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"399\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/An-Zwijsen-rond.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/An-Zwijsen-rond.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/An-Zwijsen-rond-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/An-Zwijsen-rond-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b847512 elementor-widget elementor-widget-text-editor\" data-id=\"b847512\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>An Zwijsen <\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-486548b elementor-widget elementor-widget-text-editor\" data-id=\"486548b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Professor at the Department of Cardiovascular Sciences<\/p><p>KU Leuven, Belgium<\/p><div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-2c3d155\" data-id=\"2c3d155\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-00d2cc9 elementor-widget elementor-widget-text-editor\" data-id=\"00d2cc9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>An Zwijsen is a developmental biologist. She received her PhD at the University of Antwerp in 1995. She was EMBO and ESF post-doctoral fellow with Christine Mummery at the Hubrecht Laboratory (NIOB, Utrecht, The Netherlands). Here, she became interested in the context dependent role of TGF\u03b2 signaling in the mouse embryo. After her return to Belgium, she joined Danny Huylebroeck in the Laboratory of Molecular Biology (Celgen) (VIB, University of Leuven, Belgium) in mid-1997, where she started studying BMP signaling. She became a KU Leuven faculty member in 2004 in the department of Human Genetics. She established her own lab &#8211; the Laboratory of Developmental Signaling \u2013 and was VIB groupleader (VIB Center for the Biology of Disease) in 2008-2015. In 2017, she joined with her team the Department of Cardiovascular Sciences, where she continues her research on the role of BMP signaling in vascular and lymphatic development and remodeling. She is a full Professor and coordinates several courses at KU Leuven and Kulak. She is also the president of the Ethics Committee for Animal Experimentation of KU Leuven.\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c483fc7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c483fc7\" data-element_type=\"section\" id=\"bio-Alitalo\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-87ec0b3\" data-id=\"87ec0b3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-35b01e5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"35b01e5\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-88fe30b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"88fe30b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6135f83\" data-id=\"6135f83\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-389a59f elementor-widget elementor-widget-image\" data-id=\"389a59f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"401\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Kari-Alitalo-rond1.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Kari-Alitalo-rond1.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Kari-Alitalo-rond1-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/Kari-Alitalo-rond1-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a57dc7 elementor-widget elementor-widget-text-editor\" data-id=\"3a57dc7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Kari Alitalo<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0057476 elementor-widget elementor-widget-text-editor\" data-id=\"0057476\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Director of the Translational Cancer Medicine Research Program and Scientific Director of the iCAN Digital Precision Cancer Medicine Flagship in the Faculty of Medicine at the University of Helsinki, Finland<\/p><p>Director of the Wihuri Research Institute<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-8bb004e\" data-id=\"8bb004e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d9b1924 elementor-widget elementor-widget-text-editor\" data-id=\"d9b1924\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Kari Alitalo obtained an M.D. and Ph.D. in Medical Science from the University of Helsinki, Finland. He has previously worked as Professor of Medical Biochemistry, in University of Turku, Finland, as Research Professor in the Finnish Cancer Institute, and as Director of the Academy of Finland Centre of Excellence in Translational Cancer Biology at the University of Helsinki and University of Turku.<\/p><p>Dr. Alitalo and collaborators work on translational aspects of vascular growth factors in development, physiology and in human cancer, cardiovascular and neurological diseases, and obesity. Of special interest are the angiopoietins and their Tie1 and Tie2 receptor complex, lymphangiogenic growth factor VEGF-C and its receptor VEGFR-3, and VEGF-B as a growth factor for coronary and adipose vasculature. The laboratory has demonstrated VEGF-C induced tumor lymphangiogenesis and metastasis and developed inhibitors of the VEGFR-3 signal transduction pathway, which are in phase two clinical trials in age-related macular degeneration and diabetic macular edema, and growth factor therapy for lymphedema, which has gone through a phase two clinical trial. A recent finding by the laboratory was the discovery of meningeal lymphatic vessels.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e2c2b9f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e2c2b9f\" data-element_type=\"section\" id=\"bio-Bischoff\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-293c4f5\" data-id=\"293c4f5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a3ecd9 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8a3ecd9\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-458e417 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"458e417\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-dee775c\" data-id=\"dee775c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b2e0c1 elementor-widget elementor-widget-image\" data-id=\"5b2e0c1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" src=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/J-Bischoff-rond.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/J-Bischoff-rond.png 400w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/J-Bischoff-rond-300x300.png 300w, https:\/\/vacure-conference.net\/wp-content\/uploads\/2022\/07\/J-Bischoff-rond-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-947c8d0 elementor-widget elementor-widget-text-editor\" data-id=\"947c8d0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Joyce Bischoff<\/h3>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-064d9af elementor-widget elementor-widget-text-editor\" data-id=\"064d9af\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Ensign Professor of Medicine (Cardiology) and Professor of Cellular And Molecular Physiology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, USA<\/p><p>Co-Director, Yale Cardiovascular Research Center (YCVRC)<\/p><div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-f17104a\" data-id=\"f17104a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73cd387 elementor-widget elementor-widget-text-editor\" data-id=\"73cd387\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The lab of Joyce Bischoff is dedicated to uncovering mechanisms that cause vascular malformations, vascular tumors and drive endothelial plasticity. She embarked on this research when she was recruited to Boston Children\u2019s Hospital and Harvard Medical School as an Assistant Professor. She soon became intrigued by the unique vascular overgrowth in infantile hemangioma (IH) and studied it through collaborations with Dr. John Mulliken, a vascular anomalies pioneer at Boston Children\u2019s Hospital. They identified a unique vasculogenic cell that forms IH-like vessels in mice.\u00a0 Their recent work showed the non-beta blocker enantiomer of propranolol blocks endothelial differentiation in vitro and IH vessel formation in vivo by disrupting the transcription factor SOX18.<\/p><p>Over the last several years, she has expanded her research to vascular malformations. The team showed human endothelial cells (EC) transduced to express a somatic activating mutation in TIE2 are sufficient to create venous malformations in immune-deficient mice, and that rapamycin can stop the venous malformation enlargement in the mouse model. This led to a phase 2a clinical trial. They also showed the somatic activating mutation in GNAQ, found in skin and brain capillary malformations (CM), is enriched in ECs from these lesions, which pinpoints the cellular context for elucidating disease mechanisms. They recently showed endothelial cells expressing the mutant allele are sufficient to form CM-like vessels in mice and that ANGPT2 is involved in the abnormal CM vessel formation.\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Keynote speakers Anne Eichmann \u00a0 Ensign Professor of Medicine (Internal Medicine-Cardiology) Yale University, New Haven, USA Dr. Eichmann obtained her M.Sc. at the Weizmann Institute in Rehovot, Israel, and a Ph.D. in molecular and cell biology from the Universit\u00e9 Paris XIII. She came to Yale School of Medicine in 2010, where she now is Ensign &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/vacure-conference.net\/index.php\/keynote-speakers\/\"> <span class=\"screen-reader-text\">Keynote speakers<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"class_list":["post-973","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/pages\/973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/comments?post=973"}],"version-history":[{"count":41,"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/pages\/973\/revisions"}],"predecessor-version":[{"id":3060,"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/pages\/973\/revisions\/3060"}],"wp:attachment":[{"href":"https:\/\/vacure-conference.net\/index.php\/wp-json\/wp\/v2\/media?parent=973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}